Relationship between Hemostatic Factors and the Platelet Index in Patients with Ischemic Heart Disease
- 1 January 2006
- journal article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 35 (5), 388-391
- https://doi.org/10.1159/000097694
Abstract
To understand the heterogeneity of platelets, we investigated the correlation between hemostatic factors and the platelet index [platelet count, mean platelet volume (MPV), platelet-large cell ratio (P-LCR) and platelet distribution width (PDW)] in patients with ischemic heart disease (IHD). Ninety-seven patients with IHD and 120 aged controls (AC) were enrolled in the study. D-dimer, thrombin-antithrombin III complex (TAT), von Willebrand factor antigen (VWF:Ag) and platelet indexes were measured in the peripheral venous blood. The D-dimer and TAT levels in the patients were significantly elevated compared to the AC. VWF:Ag was also elevated, but not significantly so. However, no differences were observed in the platelet index between the patients and the AC. In the patients, the level of VWF:Ag was significantly inversely correlated with the platelet count, but such correlations were not observed in the D-dimer and TAT. TAT was significantly positively correlated with MPV, P-LCR and PDW. VWF:Ag was also correlated, though not significantly, with MPV, P-LCR and PDW. The D-dimer was not correlated with the platelet index. In the AC, the platelet count was inversely correlated with VWF:Ag, but not significantly so. VWF:Ag showed significant positive correlations with MPV, P-LCR and PDW. However, the D-dimer and TAT were not correlated with the platelet index in AC. These findings suggest that VWF:Ag and TAT seem to be profoundly related to platelet volume.Keywords
This publication has 14 references indexed in Scilit:
- Evaluation of Platelet Indexes in Patients with Aortic AneurysmPathophysiology of Haemostasis and Thrombosis, 2005
- Endothelial Cell Markers and the Risk of Coronary Heart DiseaseCirculation, 2004
- Coagulation activation in young survivors of myocardial infarction (MI) - a population-based case-control studyThrombosis and Haemostasis, 2004
- The Importance of von Willebrand Factor Level and Heart Rate Changes in Acute Coronary Syndromes: A Comparison with Chronic Ischemic ConditionsAngiology, 2003
- Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery diseaseBritish Journal of Haematology, 2002
- Coagulation Activity and Clinical Outcome in Unstable Coronary Artery DiseaseArteriosclerosis, Thrombosis, and Vascular Biology, 2001
- Platelet Reactivity in Acute Coronary Syndromes: Evidence for Differences in Platelet Behaviour between Unstable Angina and Myocardial InfarctionThrombosis and Haemostasis, 2001
- Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest painEuropean Heart Journal, 1998
- Clinical Significance of Thrombosis-Related Markers in Ischemic Heart DiseaseJapanese Journal of Thrombosis and Hemostasis, 1993
- Study of von Willebrand factor and protein C in patients with myocardial infarction.Blood & Vessel, 1988