INTERACTIONS OF ESTRONE AND PROLACTIN WITH SPECIAL REFERENCE TO THE EFFECT OF ESTRONE ON THE PIGEON CROP-GLAND RESPONSE

Abstract

The inhibiting effects of various doses of estrone on the response of the pigeon crop gland to prolactin were studied. With a given level of prolactin the absolute amt. of crop growth prevented by estrone adm. rose to a maximum with increasing doses of estrone which was higher when the daily dose of prolactin was 3 rng. than when the daily dose was 1.5 mg. The % inhibition due to estrone adm. also rose to a maximum with increasing doses of estrone but the maximum was the same for both levels of prolactin, and for the prep. used was equal to about 54%. Relatively high doses of crop-stimulating extracts of ant. lobe did not inhibit the vaginal response to estrone in the ovariectomized mouse. Estrone and prolactin exerted antagonistic effects on the body wt. of the pigeon, prolactin tending to increase and estrone to decrease the wt.