An upper limit to the number of sodium channels in nerve membrane?
- 1 January 1967
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 188 (1), 99-105
- https://doi.org/10.1113/jphysiol.1967.sp008126
Abstract
A small volume of artificial sea water containing 300 nM tetrodotoxin (TTX) was applied successively to seven lobster nerve trunks and the cumulative uptake of toxin investigated by bio-assay. Light and electron microscopy indicated that the nerve trunks had a total axonal area of 0.7 x 104 cm2/g. Sodium analysis gave a sodium space for the nerve trunks of 30%. The. amount of toxin taken by up the cells in 1 g of nerve is less than 6 x 10-11 moles. There are probably fewer than 13 sodium channels/[mu]2 axon in lobster nerve.This publication has 6 references indexed in Scilit:
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- Voltage clamp experiments on internally perfused giant axons.The Journal of Physiology, 1965
- Tarichatoxin—Tetrodotoxin: A Potent NeurotoxinScience, 1964
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- The positive and negative heat production associated with a nerve impulseProceedings of the Royal Society of London. B. Biological Sciences, 1958