Subthalamic nucleotomy alleviates parkinsonism in the 1 -methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-exposed primate
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in British Journal Of Neurosurgery
- Vol. 6 (6), 575-582
- https://doi.org/10.3109/02688699209002375
Abstract
Research into the neural mechanisms underlying the symptoms of parkinsonism utilizing the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed primate model have shown that the subthalamic nucleus (STN) occupies a central role. As a logical development of this theory, we have studied the effects of thermocoagulative lesions of the STN in the primate model. Such lesions can cause remarkable symptom reversal in the experimental primate model.Keywords
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