Transcription — guarding the genome by sensing DNA damage
- 1 September 2004
- journal article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 4 (9), 727-737
- https://doi.org/10.1038/nrc1435
Abstract
Cells induce the expression of DNA-repair enzymes, activate cell-cycle checkpoints and, under some circumstances, undergo apoptosis in response to DNA-damaging agents. The mechanisms by which these cellular responses are triggered are not well understood, but there is recent evidence that the transcription machinery might be used in DNA-damage surveillance and in triggering DNA-damage responses to suppress mutagenesis. Transcription might also act as a DNA-damage dosimeter where the severity of blockage determines whether or not to induce cell death. Could transcription therefore be a potential therapeutic target for anticancer strategies?Keywords
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