HEREDITARY RENAL ADENOMAS AND ADENOCARCINOMAS IN RATS

Abstract

An animal model of renal adenomas and adenocarcinomas is described in rats where tumor development depends on an autosomal dominant gene. This gene seems to have a direct effect on the kidney. Most of the tumors develop from the proximal convoluted tubules. This is the 1st known animal model where kidney tumors develop on an hereditary basis. The histopathology of the renal tumors not only resembles that of chemically induced rat kidney tumors but also human tumors.