COMPARISON BETWEEN LUMINOL- AND LUCIGENINDEPENDENT CHEMILUMINESCENCE OF POLYMORPHONUCLEAR LEUKOCYTES
- 15 August 2009
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Series C: Immunology
- Vol. 92C (1-6), 357-361
- https://doi.org/10.1111/j.1699-0463.1984.tb00100.x
Abstract
Phorbolmyristate acetate (PMA) induced both a luminol- and a lucigenin-dependent chemiluminescence response in normal polymorphonuclear leukocytes (PMNL). PMNL isolated from a patient with a myeloperoxidase (MPO)-deficiency produced almost no luminol-dependent chemiluminescence. The lucigenin-dependent chemiluminescence response did not differ between normal and MPO-deficient cells. Thus, luminol- and lucigenin-dependent chemiluminescence differ in their dependence on MPO. Results obtained with cell-free MPO-H2O2- and superoxide anion-producing systems further supported this conclusion.Keywords
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