Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans
- 1 June 2009
- journal article
- Published by Wolters Kluwer Health in European Journal of Gastroenterology & Hepatology
- Vol. 21 (6), 667-672
- https://doi.org/10.1097/meg.0b013e3283196adc
Abstract
The pathogenesis of fatty liver is likely to depend on a complex interaction of environmental and genetic factors. We investigated a large-scale analysis of the association between microsomal triglyceride transfer protein (MTTP) and phosphatidylethanolamine N-methyltransferase (PEMT) polymorphism in alcoholic and nonalcoholic fatty liver disease. Five hundred and eighty-eight patients who visited the health promotion center were enrolled. To elucidate the possible role of genetic variation affecting triglyceride metabolism in fatty liver disease, the MTTP-I128T and PEMT-V175M polymorphisms were studied. The I/I genotype and I allele frequency of MTTP polymorphism with alcoholic fatty liver was significantly higher than that of the normal control group (P=0.026 vs. 0.005). Genotype and allele frequency of PEMT, however, did not show a significant difference between control and fatty liver. I/I genotype of MTTP gene frequency in the drinkers with fatty livers was 85.4%, which was significantly higher than that in the drinkers without fatty liver, which was 68.4% (P=0.013). With regard to biochemical indicators, the alanine aminotransferase value of the I/I group was significantly higher than that of the I/T and T/T groups (P=0.04). Asparate aminotransferase, gamma-glutamyl transpeptidase, triglyceride, apolipoprotein B, and glucose concentration tended to be lower in the I/T and T/T groups than in the I/I group, but no statistically significant difference was found. In this study, MTTP-I128T polymorphism is associated with central obesity, elevated liver enzymes, and alcoholic fatty liver disease.Keywords
This publication has 25 references indexed in Scilit:
- Obesity and Nonalcoholic Fatty Liver DiseaseNutrition Reviews, 2007
- The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese populationJournal of Hepatology, 2007
- Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish womenDrug and Alcohol Dependence, 2006
- The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitisCell Metabolism, 2006
- THE ROLE OF GENETIC POLYMORPHISMS IN ALCOHOLIC LIVER DISEASEAlcohol and Alcoholism, 2006
- Diagnosis and Management of the Metabolic SyndromeCirculation, 2005
- Are genetic polymorphisms of tumour necrosis factor alpha, interleukin-10, CD14 endotoxin receptor or manganese superoxide dismutase associated with alcoholic liver disease?European Journal of Gastroenterology & Hepatology, 2005
- Nonalcoholic fatty liver disease and the epidemic of obesity.Cleveland Clinic Journal of Medicine, 2004
- Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitisJournal of Hepatology, 2004
- Prospective evaluation of the diagnostic accuracy of liver ultrasonography.Gut, 1981