Pulmonary oedema induced by ANTU, or by high or low oxygen concentrations in rat--an electron microscopic study.
- 1 August 1972
- journal article
- Vol. 53 (4), 347-58
Abstract
Pulmonary oedema has been experimentally induced in rats using either an intraperitoneal injection of alpha-naphthyl thiourea (ANTU) or by variation of atmospheric oxygen content. For the first time an electron microscopic study of the development of ANTU-induced lung oedema has been made. At 2 hours blebbing and scalloping of endothelial cells and interstitial oedema were observed, each showing increasing severity with increase of dose—3, 10 and 50 mg/kg doses. By 6 hours, in the 50 mg/kg treated animals, epithelial damage was also apparent. No alteration in mean alveolar size or in the distribution of alveolar lining cells was found. The breathing rate of the rats was slowed for the first 3 hours and then increased well above normal levels.This publication has 25 references indexed in Scilit:
- Morphometric estimation of pulmonary diffusion capacityRespiration Physiology, 1971
- The alveolar wallRespiratory Medicine, 1970
- Ultrastructural changes in pulmonary oedema produced experimentally with ammonium sulphateThe Journal of Pathology, 1970
- Reaction of the lung cells to a high concentration of oxygen.1968
- THE ULTRASTRUCTURE OF THE PULMONARY ALVEOLAR VESSELS IN MENDELSON'S (ACID PULMONARY ASPIRATION) SYNDROMEBritish Journal of Anaesthesia, 1968
- Vascular permeability changes during experimentally produced pulmonary oedema in ratsThe Journal of Pathology and Bacteriology, 1966
- SIMPLE METHODS FOR "STAINING WITH LEAD" AT HIGH pH IN ELECTRON MICROSCOPYThe Journal of cell biology, 1961
- Pulmonary mechanics during induced pulmonary edema in anesthetized dogsJournal of Applied Physiology, 1959
- THE PHYSIOLOGY AND CYTOLOGY OF PULMONARY EDEMA AND PLEURAL EFFUSION PRODUCED IN RATS BY ALPHA-NAPHTHYL THIOUREA (ANTU)*Journal of Thoracic Surgery, 1952
- The lining of the alveoli in mice, rats, dogs, and frogs following acute pulmonary edema produced by ANTU poisoningThe Anatomical Record, 1949