High-Capacity Adenoviral Vectors for Gene Transfer and Somatic Gene Therapy
- 10 October 1999
- journal article
- review article
- Published by Mary Ann Liebert Inc in Human Gene Therapy
- Vol. 10 (15), 2451-2459
- https://doi.org/10.1089/10430349950016807
Abstract
The availability of efficient and nontoxic gene delivery technologies is fundamental to the translation of therapeutic concepts into clinical practice by gene transfer. High-capacity adenoviral (HC-Ad) vectors are characterized by the ability to transduce cells in vitro and in vivo with more than 30 kb of nonviral DNA. This quality allows simultaneous gene transfer of several expression cassettes, large promoters, and some genes in their natural genomic context. Because all viral coding sequences are removed from these vectors, safety is considerably improved compared with previous-generation adenoviral vectors.Keywords
This publication has 80 references indexed in Scilit:
- Adenoviral Gene Therapy Leads to Rapid Induction of Multiple Chemokines and Acute Neutrophil-Dependent Hepatic Injury in VivoHuman Gene Therapy, 1999
- Adenoviral preterminal protein stabilizes mini-adenoviral genomes in vitro and in vivoNature Biotechnology, 1997
- Adenovirus-mediated gene transfer: influence of transgene, mouse strain and type of immune response on persistence of transgene expressionGene Therapy, 1997
- Persistent transgene expression in mouse liver following in vivo gene transfer with a ΔE1/ΔE4 adenovirus vectorGene Therapy, 1997
- In Vivo Expression of Full-Length Human Dystrophin from Adenoviral Vectors Deleted of All Viral GenesHuman Gene Therapy, 1996
- Intratracheal Gene Delivery with Adenoviral Vector Induces Elevated Systemic IgG and Mucosal IgA Antibodies to Adenovirus andβ-GalactosidaseHuman Gene Therapy, 1995
- Encapsidation of adenovirus 16 DNA is directed by a small DNA sequence at the left end of the genomeCell, 1980
- The structure and expression of two defective adenovirus 2/simian virus 40 hybridsJournal of Molecular Biology, 1978
- Viral DNA sequences from incomplete particles of human adenovirus type 7Cell, 1977
- Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5Journal of General Virology, 1977