Chromosome breaks and sister chromatid exchanges in albinos in Nigeria
- 1 January 1979
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 15 (1), 17-21
- https://doi.org/10.1111/j.1399-0004.1979.tb02024.x
Abstract
The prevalence of squamous cell carcinoma of the skin in albinos reaches approximately 90 % in patients over 20 years of age in the vicinity of Enugu, Nigeria. Chromosome breaks and sister chromatid exchanges (SCE) were evaluated in tyrosinase-positive oculocutaneous albinos and pigmented controls of Ibo extraction who were life-long residents of Nigeria. No difference in the frequency of chromosomal breaks in 14 albinos compared to 6 pigmented controls, and no differences in the frequency of SCE in 9 albinos compared to 3 controls could be detected. Increased chromosomal abnormalities in lymphocytes do not appear to be associated with albinism or fulminating skin cancer present in albinos in the tropics.Keywords
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