THE KINETICS OF THE EXCHANGE BETWEEN TRANSCORTIN-BOUND AND UNBOUND CORTISOL IN PLASMA
- 1 April 1968
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 40 (4), 457-465
- https://doi.org/10.1677/joe.0.0400457
Abstract
SUMMARY: In order to determine the probable availability of protein-bound cortisol to the tissues, the establishment of equilibrium between transcortin-bound [3H]cortisol and unbound [14C]cortisol in plasma has been followed using Sephadex gel filtration. Association of cortisol with transcortin was rapid; dissociation of the steroid-protein complex was comparatively slow; when the binding-sites were nearly saturated the half-dissociation times of [3H]cortisol were 25 min. at 4°, 1 min. at 22° and about 10 sec. at 37°.This publication has 8 references indexed in Scilit:
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