The Effect of Carbon Tetrachloride Poisoning on Serum Lipoproteins Associated with Atherosclerosis

Abstract

Carbon tetrachloride was injected into normal rabbits and the levels of S_f 3-12, 12-20, and 20-40 classes of lipoproteins were determined during the course of these injections. A marked increase in concentration of these three classes of lipoproteins occurred during the administration of carbon tetrachloride. After the cessation of this drug, the lipoproteins of largest S_f rate returned to normal first with those of lower S_f rate returning to normal levels in the order of decreasing S_f rates. Rabbits fed cholesterol were also injected with carbon tetrachloride, and their lipoproteins continued to increase after cessation of this drug.