Distribution of Tritium Labeled Human Growth Hormone in Rats and Guinea Pigs.

Abstract

Summary 1. Biologically active labeled human growth hormone, prepared by limited acetylation with tritiated acetic anhydride, was injected intravenously into rats and guinea pigs. 2. In both rats and guinea pigs the radioactivity was distributed primarily to skeletal muscle, liver, intestine, kidney, bone, fat, and urine. 3. Autoradiographic studies indicated that intravenously injected human and bovine growth hormone were concentrated in proximal renal tubular cells of both rats and guinea pigs.