Studies on the polyoma-virus-induced tumor-specific transplantation antigen (TSTA) - does middle or large T-antigen play a role?
- 1 September 1984
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 34 (3), 403-406
- https://doi.org/10.1002/ijc.2910340318
Abstract
Mice and rats could be immunized against the polyoma‐virus‐induced tumor‐specific transplantation antigen (TSTA) by repeated inoculation of frozen or irradiated cells of an MT‐cDNA‐transformed rat cell line (2.8) that contains only the polyoma middle T‐antigen, or by cells that carried a host range mutant and expressed a full‐length large T‐antigen, but only non‐functional N‐terminal fragments of small and middle T. This shows that neither large T nor an intact middle T is necessary to elicit a polyoma tumor‐specific graft rejection response. Either one of them is sufficient by itself.This publication has 16 references indexed in Scilit:
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