Reductive Amination of Aldehydes and Ketones with Weakly Basic Anilines Using Sodium Triacetoxyborohydride

Abstract

The weakly basic chloro-, nitro-, cyano-, ethoxy- carbonyl- and carboxy-substituted anilines react with aldehydes and ketones under reductive amination conditions, employing sodium triacetoxyborohydride, to give excellent yields of the corresponding secondary aromatic amines.