Human type I procollagen genes are located on different chromosomes.
- 1 November 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (21), 6627-6630
- https://doi.org/10.1073/pnas.79.21.6627
Abstract
A recombinant plasmic containing sequences complementary to human pro-.alpha.1(I) collagen mRNA was used for the chromosomal assignment of the pro-a1(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosomes with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-A1(I) gene with the segment 17q21 .fwdarw. qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.This publication has 30 references indexed in Scilit:
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