Iodipamide (Cholografin) Administration

Abstract

AFTER the administration of iodine-containing x-ray contrast mediums, such as iodoalphionic acid (Priodax), iodopyracet (Diodrast) and iodinated oil (Lipiodol), a decrease in the thyroid uptake of radio-active iodine (I¹³¹) and an increase in the serum precipitable iodine occur. These effects are considered to be a result of the liberation of iodide from these organic molecules.¹ In a recently developed x-ray contrast medium, iodipamide (Cholografin, disodium N, N'-adipyl-bis [3-amino-2,4,6,-triiodo] benzoic acid),§ the iodine content was found to remain firmly bound in the molecule after its intravenous injection.² This observation suggested that this medium might not alter the thyroid uptake of . . .