Genome organization and transactivation of the human immunodeficiency virus type 2
- 1 April 1987
- journal article
- Published by Springer Nature in Nature
- Vol. 326 (6114), 662-669
- https://doi.org/10.1038/326662a0
Abstract
Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of limited sequence homology; this may help the determination of the structure-function relationships of the different viral elements.Keywords
This publication has 64 references indexed in Scilit:
- The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brainCell, 1986
- The trans-activator gene of the human T cell lymphotropic virus type III is required for replicationCell, 1986
- AIDS Virus Infection in Nairobi ProstitutesNew England Journal of Medicine, 1986
- SEROLOGICAL EVIDENCE FOR VIRUS RELATED TO SIMIAN T-LYMPHOTROPIC RETROVIRUS III IN RESIDENTS OF WEST AFRICAThe Lancet, 1985
- The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeatCell, 1985
- T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAVNature, 1984
- The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirusNature, 1984
- ISOLATION OF HUMAN T-LYMPHOTROPIC RETROVIRUS (LAV) FROM ZAIRIAN MARRIED COUPLE, ONE WITH AIDS, ONE WITH PRODROMESThe Lancet, 1984
- Acquired Immunodeficiency Syndrome in African PatientsNew England Journal of Medicine, 1984
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983