Development of a Standardized Analysis Strategy for Basic Drugs, Using Ion-Pair Extraction and High-Performance Liquid Chromatography PART IV. Application to Solid Pharmaceutical Dosage Forms

Abstract

The usefulness of two standardized HPLC-systems for the analysis of basic drugs in tablets and capsules is exemplified. The standardized HPLC systems both use a CN-column combined with either a polar or a non polar mobile phase. Also the sample preparationis standardized and simple; it involves suspension of the powder mixture in one of the mobile phase components, centrifugation and injection of the clear supernatant.