Histamine as Possible Chemical Mediator for Cutaneous Pain. Dual Pain Response to Histamine

Abstract

Histamine introduced into the superficial layers of the skin of human subjects causes an immediate as well as a latent painful sensation. The intensity and the duration of the response are directly proportional to the concn. of histamine. The lapse of time between the primary and the latent secondary response is inversely proportional to the concn. of histamine. These findings give further support to the theory that histamine or a histamine-like substance may be the chemical mediator for cutaneous pain.