Many cases of reactivation, perforation, and hemorrhage in old ulcers and the production of new ulcers in patients who received corticotropin (ACTH) or cortisone intramuscularly have been reported.1Recently, Moe2reviewed the literature and reported a case of gastric ulcer appearing during oral cortisone therapy, but a search of available literature fails to reveal a case of peptic ulcer with massive hemorrhage arising during such therapy. The following case is presented as the first such case described. REPORT OF A CASE W. H., a white married tool and die maker, aged 29, was admitted to the Ravenswood Hospital on Jan. 17, 1952, complaining of weakness and dizziness. He had had tarry stools for six days and one emesis of "coffee ground" material seven days before admission. He had not had any gastrointestinal symptoms previously. He had been well until 1946, when a Marie-Strümpell type of arthritis developed. No