New Insights into mTOR Signaling: mTORC2 and Beyond
- 21 April 2009
- journal article
- perspective
- Published by American Association for the Advancement of Science (AAAS) in Science Signaling
- Vol. 2 (67), pe27
- https://doi.org/10.1126/scisignal.267pe27
Abstract
The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid–induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.Keywords
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