Effects of Oxidized Fatty Acids on Ascites Tumor Metabolism

Abstract

Extracts of irradiated methyl linolenate and methyl linoleate inhibited respiratory and glycolytic activities of Ehrlich ascites tumor cells. Respiration was more sensitive than glycolysis to the oxidation products of both esters. Oxidation products of methyl linolenate inhibited both glycolysis and respiration at lower concentrations than those of methyl linoleate. In contrast to the normal tissues of the mouse, the oxidation of tumor cell lipids by aerobic incubation and UV light could not be shown by the thiobarbituric acid reaction. Analyses of unsaturated fatty acids of ascites tumor cells are presented.