Basic fibroblast growth factor protects cerebellar neurons in primary culture from NMDA and non‐NMDA receptor mediated neurotoxicity
- 14 November 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 335 (1), 124-131
- https://doi.org/10.1016/0014-5793(93)80453-2
Abstract
We have investigated the ability of bFGF to protect cerebellar neurons from neurotoxicity by excitatory amino acids. We have found that preincubation with 1-2.5 nM bFGF for 1-6 days significantly protected neurons from excitotoxic damage via NMDA receptors as well as ionotropic non-NMDA receptors. bFGF neuroprotection appeared not to be dependent upon neuronal differentiation and was not mimicked by other neurotrophins including BDNF, NT-3 and NGF. A greater rise in extracellular calcium-dependent cGMP formation, following either depolarization or excitatory amino acid receptor activation was observed in bFGF-pretreated neurons. We suggest that neuroprotection from excitotoxicity following bFGF treatment may be associated to the modulation of neurochemical pathways dependent upon extracellular calcium influx.Keywords
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