Binding of 7,12-dimethylbenz[α]anthracene to DNA investigated by tritium displacement

Abstract

7,12-Dimethylbenz[α]anthracene, specifically labelled with tritium in the 7-methyl group, has been prepared and then bound covalently to DNA both photochemically in vitro and metabolically in vivo; a significant proportion of the tritium is displaced in both cases.