Relationship between serum gastrin concentration and lower-esophageal sphincter pressure
- 1 March 1975
- journal article
- research article
- Published by Springer Science and Business Media LLC in Digestive Diseases and Sciences
- Vol. 20 (3), 201-207
- https://doi.org/10.1007/bf01070722
Abstract
Serum gastrin concentration [G] has been proposed as the major factor regulating resting lower-esophageal sphincter pressure (LESP). Available supporting evidence in man, however, is largely circumstantial. The present study directly compares measurements of LESP with concurrent levels of circulating serum gastrin in fasting human subjects. A direct correlation was not shown betwen [G] and resting LESP; rather, a trend existed toward an inverse relationship. The study results indicate that the concentration of serum immunoreactive gastrin is not a major determinant of lower-esophageal sphincter tone in humans.Keywords
This publication has 27 references indexed in Scilit:
- The interaction of glucagon and pentagastrin on the lower oesophageal sphincter in man and dogGut, 1973
- The Mechanics of Esophageal Muscle Contraction. EVIDENCE OF AN INOTROPIC EFFECT OF GASTRINJCI Insight, 1973
- Pathogenesis of Lower-Esophageal-Sphincter IncompetenceNew England Journal of Medicine, 1973
- Inhibition of the lower oesophageal sphincter by fat a mechanism for fatty food intoleranceGut, 1973
- The Genesis of Lower Esophageal Sphincter Pressure: Its Identification through the Use of Gastrin AntiserumJCI Insight, 1972
- Role of gastrin supersensitivity in the pathogenesis of lower esophageal sphincter hypertension in achalasiaJCI Insight, 1971
- Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretinJCI Insight, 1971
- Gastrin and its ActivitiesNature, 1970
- Hormonal Control of Gastroesophageal-Sphincter StrengthNew England Journal of Medicine, 1970
- Action of gastrin on the lower oesophageal sphincter in manGut, 1969