Studies on peptides. 68. Synthesis of the tritriacontapeptide amide corresponding to the entire amino acid sequence of the desulfated form of porcine cholecystokinin-pancreozymin (CCK-PZ).
- 1 January 1976
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 24 (11), 2794-2802
- https://doi.org/10.1248/cpb.24.2794
Abstract
The tritriacontapeptide amide, [27-Tyr]-CCK-PZ, was synthesized by successive azide condensation of 4 peptide fragments, (1-5), (6-11), (12-16), and (17-33), followed by exposure to hydrogen fluoride to remove all protecting groups. Though the CCK-PZ activity of synthetic peptide was only 1/250 of the standard from the natural source, it was smoothly labeled with radioactive iodine. Chain length activity relationship of CCK-PZ was also discussed.This publication has 4 references indexed in Scilit:
- Studies on peptides. 67. Synthesis of the hexadecapeptide corresponding to position 1 through 16 of porcine cholecystokinin-pancreozymin (CCK-PZ).CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- Studies on peptides. 66. Synthesis of the protected heptadecapeptide amide related to the C-terminal portion of porcine cholecystokinin-pancreozymin (CCK-PZ).CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- Studies on peptides. 62. Synthesis of the protected octadecapeptide corresponding to positions 26 through 43 of porcine gastic inhibitory polypeptide (GIP).CHEMICAL & PHARMACEUTICAL BULLETIN, 1976
- TYROSINE-O-SULFATE AS A CONSTITUENT OF NORMAL HUMAN URINEJournal of Biological Chemistry, 1955