THE EFFECTS OF FLUORIDE FEEDING ON THE ORGANIC MATRIX OF BONES AND TEETH OF PIGS AS OBSERVED BY AUTORADIOGRAPHY AFTER IN VITRO UPTAKE OF CA45 AND S35

Abstract
Demineralized sections of fluorinated bones and teeth were studied by autoradipgraphy following in vitro uptake of Ca45 or S35O4. The portions of tissue which do not become mineralized (cartilage, prebone, predentine, and precementum) show an increased Ca45 uptake apparently related to an increase in chondroitin sulfate content in fluorosis. The tissues from the fluoride-fed animals show an increase of in vitro uptake of S in the tissues which become mineralized (bone, dentine, cementum).