THE EFFECTS OFp-HYDROXYPROPIOPHENONE ON THE THYROID GLAND OF EXPERIMENTAL ANIMALS*

Abstract

These studies show that p-hydroxypropiophenone in large doses has little influence on thyroid function as measured by I131 collection in the rat and chick. No evidence of stimulation or inhibition of adrenal or gonadal function was observed. Parenteral admn. of the drug to rats on a low-iodine diet decreased the collection of I131 by the thyroid roughly in proportion to the dose of p-hydroxypropiophenone. The possible mechanism of this effect is considered. The compound failed to inhibit the formation of a goiter in animals treated with thiouracil.