The Cardiovascular Effects of Neuropeptide Y (NPY)
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 6 (10-11), 1889-1892
- https://doi.org/10.3109/10641968409046098
Abstract
NPY (1ng-10/micrograms) had no effect on mean arterial pressure (MAP) or heart rate (HR) when administered into the lateral brain ventricle or cisterna magna of conscious, chronically instrumented normotensive, male Wistar rats. However upon intravenous injection (0.1-5/micrograms) it produced a dose related pressor response accompanied by bradycardia. This pressor effect was not influenced by prazosin infusion (100 micrograms/kg/min). These results suggest that NPY has no direct role in central cardiovascular regulation, but peripherally is a very potent vasoconstrictor peptide.Keywords
This publication has 7 references indexed in Scilit:
- Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the ratNeuroscience, 1984
- Transmitter and Peptide Systems in Areas Involved in the Control of Blood PressureClinical and Experimental Hypertension. Part A: Theory and Practice, 1984
- Neuropeptide Y in vitro selectively increases the number of α2‐adrenergic binding sites in membranes of the medulla oblongata of the ratActa Physiologica Scandinavica, 1983
- Central administration of neuropeptide Y induces hypotension bradypnea and EEG synchronization in the rat*Acta Physiologica Scandinavica, 1983
- Neuropeptide Y (NPY)‐like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic functionActa Physiologica Scandinavica, 1982
- Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptideNature, 1982
- ON THE ROLE OF CENTRAL ADRENALINE NEURONS IN CENTRAL CARDIOVASCULAR REGULATIONPublished by Elsevier ,1980