B cell tolerance induced by polymeric antigens V. Different avidities of primed and virgin precursor cells for paucivalent antigen
- 1 May 1976
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 6 (5), 379-382
- https://doi.org/10.1002/eji.1830060514
Abstract
We have compared the avidity of virgin and primed hapten-specific precursor cells for DNP-lys-S3 (dinitrophenylated type 3 pneumococcal polysaccharide) by measuring its capacity to prevent them from binding highly radioactive DNP-hemocyanin, and thereby protect them from committing hapten-specific “suicide”. Moderately substituted conjugates (e.g. DNP-2.7S3) protected virgin and memory B cells impartially. In contrast, DNP-lyso0.6S3 protected memory cells efficiently, but protected virgin cells only at considerably higher concentrations. These results are consistent with previous evidence – from this and other systems – that there is a higher density of receptors on primed than on unprimed B cells – the significance of which is discussed.This publication has 20 references indexed in Scilit:
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