Hypersensitivity to Purified Trypsin and Chymotrypsin

Abstract

A NUMBER of proteolytic enzymes have gained wide acceptance for clinical use.¹ They are employed in the treatment of peripheral vascular disease, particularly superficial thrombophlebitis, for the relief of bronchial obstruction due to inspissated secretions in patients with chronic pulmonary disease, for the débridement of body surfaces covered with necrotic tissue, for the reduction of hematomas and edema resulting from trauma, in various acute ophthalmic inflammatory conditions and as an adjunct to cataract surgery.² Commercial preparations include trypsin or chymotrypsin or both, derived from mammalian pancreas, incorporated in sesame oil for intramuscular injection, in tablets for oral administration, in nose . . .