Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
Open Access
- 2 July 2012
- journal article
- Published by Springer Nature in Journal of Neuroinflammation
- Vol. 9 (1), 156
- https://doi.org/10.1186/1742-2094-9-156
Abstract
In brain tissues from multiple sclerosis (MS) patients, clusters of activated HLA-DR-expressing microglia, also referred to as preactive lesions, are located throughout the normal-appearing white matter. The aim of this study was to gain more insight into the frequency, distribution and cellular architecture of preactive lesions using a large cohort of well-characterized MS brain samples.Keywords
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