Role of pro-inflammatory cytokines in rheumatoid arthritis
- 1 January 1998
- journal article
- review article
- Published by Springer Nature in Springer Seminars in Immunopathology
- Vol. 20 (1-2), 133-147
- https://doi.org/10.1007/bf00832003
Abstract
Rheumatoid arthritis (RA) is well known to be a chronic autoimmune/inflammatory disease which leads to progressive joint damage and destruction. Less well known is the fact that in severe cases of RA, with extra-articular manifestations and multiple joint involvement, there is also a significant reduction in life expectancy [28]. Hence the need for new therapeutic agents. With the cloning of cDNAs encoding cytokines in the early to mid 1980s, it became possible to use new assays to evaluate cytokine expression in the local site of autoimmunity, the rheumatoid synovium. There were two goals. First would understanding cytokine expression help us understand the pathogenesis of RA? Secondly, would it be possible to learn enough about the cytokine network to establish possible therapeutic targets? While a complete understanding of either of these questions remains elusive, here we review the state of knowledge in early 1998, which shows that much progress has been made and that these goals have been partly reached. The clinical benefits of this knowledge are documented elsewhere in this compilation, as is the role of chemokines, anti-inflammatory cytokines and the cytokines involved in neovascularisation.Keywords
This publication has 110 references indexed in Scilit:
- Therapeutic actions of cyclosporine and anti-tumor necrosis factor ? in collagen-induced arthritis and the effect of combination therapyArthritis & Rheumatism, 1998
- Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interactionEuropean Journal of Immunology, 1995
- Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis.JCI Insight, 1994
- LOCALIZATION OF INTERLEUKIN-1α, TYPE 1 INTERLEUKIN-1 RECEPTOR AND INTERLEUKIN-1 RECEPTOR ANTAGONIST IN THE SYNOVIAL MEMBRANE AND CARTILAGE/PANNUS JUNCTION IN RHEUMATOID ARTHRITISRheumatology, 1992
- In situ hybridization of interleukin-1 in CD14-positive cells in rheumatoid arthritisClinical Immunology and Immunopathology, 1992
- Transforming growth factor-β1 in rheumatoid synovial membrane and cartilage pannus junctionClinical and Experimental Immunology, 1991
- Factors predicting a poor life prognosis in rheumatoid arthritis: an eight year prospective study.Annals Of The Rheumatic Diseases, 1989
- Tumour necrosis factor in synovial exudates.Annals Of The Rheumatic Diseases, 1988
- Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serumArthritis & Rheumatism, 1988
- Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activityNature, 1984