Letter: Analysis of hemoglobin aggregation from Gibbs-Donnan equilibrium experiments.

Abstract
Gary-Bobo and Solomon previously employed Gibbs-Donnan equilibrium studies in the assessment of the anomalous osmotic behavior of the red cell. In these studies, the interpretation was based on thermodynamic equations for ideal solutions. The nonideal aspects of concentrated Hb solutions were considered by transforming the ideal equations of Gary-Bobo and Solomon to include non-ideal contributions for the interpretation of Hb-Hb and Hb solution interactions.

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