THE RELATIONSHIP OF DIETARY FACTORS TO RAT SERUM ALKALINE PHOSPHATASE
- 1 October 1952
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Medical Sciences
- Vol. 30 (5), 378-382
- https://doi.org/10.1139/cjms52-048
Abstract
Weanling rats were fed dietary concentrations of 0%, 5%, 10%, 30%, and 91% casein. Complete absence of dietary protein resulted in death of the young animals within five weeks. Activity of serum alkaline phosphatase was at starvation levels during this period. Optimal growth was obtained at 30% dietary level of casein, and alkaline phosphatase activity was in the normal range. No effect on the enzyme could be attributed to the protein. There is a highly significant correlation between daily food consumption and serum phosphatase activity, which is attributed to the fat component of the various diets. Adult male rats were subjected to a three-week period of protein depletion, which was followed by a two-week period of protein repletion. The protein was supplied in the following forms: casein, dried brewer’s yeast, wheat gluten, casein plus wheat gluten, and dried brewer’s yeast plus gluten. Enzyme values at the end of the experiment were typical for the high fat diet (26%) which these animals were receiving. Once more there is a significant correlation between serum alkaline phosphatase activity and daily consumption of fat, whereas the protein component of the diet is without effect on the enzyme.Keywords
This publication has 10 references indexed in Scilit:
- THE EFFECTS OF SOME DIETARY DERIVED LIPIDS AND FAT SOLUBLE VITAMINS ON RAT SERUM TRIBUTYRINASE AND ALKALINE PHOSPHATASECanadian Journal of Medical Sciences, 1952
- ON THE SOURCE OF THE ALKALINE PHOSPHATASE IN RAT SERUMJournal of Biological Chemistry, 1952
- RESPONSE OF ALKALINE PHOSPHATASE OF RAT LIVER TO PROTEIN DEPLETION AND INANITIONJournal of Biological Chemistry, 1952
- THE LOSS AND REGENERATION OF RAT LIVER ENZYMES RELATED TO DIET PROTEINJournal of Biological Chemistry, 1950
- THE RELATIONSHIP OF DIETARY FACTORS TO RAT SERUM ALKALINE PHOSPHATASE: 1. THE EFFECT OF FAT, METHIONINE, AND CYSTINECanadian Journal of Research, 1950
- THE RELATION OF AMINO ACID AVAILABILITY IN DIETARY PROTEIN TO LIVER ENZYME ACTIVITYJournal of Biological Chemistry, 1949
- THE RELATIONSHIP BETWEEN SERUM ALKALINE PHOSPHATASE AND DIETARY ESSENTIAL AMINO ACIDSCanadian Journal of Research, 1949
- Studies in biochemical adaptation. Effect of diet on the intestinal phosphatase of the ratBiochemical Journal, 1949
- Biological Values of Six Partially-Purified ProteinsJournal of Nutrition, 1948
- MINIMAL PROTEIN REQUIREMENT FOR GROWTH IN THE RAT1948