The influence of coumarin on blood levels of radio labelled protein and radio labelled poly-vinyl-pyrrolidone in thermally injured rats
- 1 October 1976
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Die Gesamte Experimentelle Medizin
- Vol. 168 (3), 165-172
- https://doi.org/10.1007/bf01851314
Abstract
The evidence presented in this paper suggests that coumarin is a RES stimulator. An enhanced removal of both RPP and radio RPVP was observed beginning at or before 30 minutes and lasting up to 6 hours. Over this time, RPP removal was enhanced by an average of 40%, while RPVP removal was enhanced by 60%. Since RPVP is non-metbabolizable, its levels may be a more accurate estimate of the stimulatory effect of coumarin. This evidence fits in well previous results which have suggested that coumarin may increase the numer of phagocytic cells. Other results have shown enhancement of protein lysis by 74% over similar periods, while enhanced protease activity levels of 50% have been observed to accompany this.This publication has 11 references indexed in Scilit:
- A conservative means of reducing the intensity and duration of thermally induced oedemaBurns, 1976
- The effect of coumarin on the liver weight of thermally injured ratsZeitschrift für Die Gesamte Experimentelle Medizin, 1976
- An in vitro demonstration of proteolysis by macrophages and its increase with coumarinCellular and Molecular Life Sciences, 1975
- Effects of anti-inflammatory and other compounds on the release of lysosomal enzymes from macrophagesBiochemical Pharmacology, 1975
- Mechanism of the sustained action of histamine and bradykinin on transport of large molecules across capillary walls in the dog pawMicrovascular Research, 1974
- Effect of Cyclic AMP on Release of Lysosomal Enzymes from PhagocytesNature New Biology, 1971
- THE UPTAKE AND DIGESTION OF IODINATED HUMAN SERUM ALBUMIN BY MACROPHAGES IN VITROThe Journal of Experimental Medicine, 1967
- The cellular evolution of inflammatory granulomataThe Journal of Pathology and Bacteriology, 1966
- The mononuclear-cell response to injuryThe Journal of Pathology and Bacteriology, 1962
- Direct Determinations of Plasma, Cell, and Organ-Blood Volumes in Normal and Hypervolemic MiceExperimental Biology and Medicine, 1950