Coagulation, Hemorrhage and Thrombosis

Abstract

Genetic aspects of hemophilia. A great contribution to knowledge of human hemophilia has been made by Brinkhous and his colleagues,^{91 ,}91a who have extensively studied a hemorrhagic disorder in dogs that completely simulates the classic disease. The abnormality, which arose de novo in a strain of Irish setters,‡ has been maintained by inbreeding and by prompt, frequent and prophylactic transfusion with normal blood to bring the animals through their hazardous puppyhood. Many observations in this species agree remarkably with those in man.⁵⁹ In addition to basic information concerning the defect of hemophilia, studies in the dog have yielded valuable genetic . . .