HISTOGENESIS AND MORPHOLOGY OF NATURALLY-OCCURRING PROSTATIC-CARCINOMA IN THE ACI-SEGHAPBR RAT
- 1 January 1980
- journal article
- research article
- Vol. 43 (6), 517-522
Abstract
The prostates of 201 male virgin or breeder ACI (ACI/segHapBR) rats, 24-40mo. of age were reviewed histologically, and the genesis of prostatic carcinoma was studied. At 24 mo. of age, 35-45% of the rats had the earliest lesions, intraalveolar atypical hyperplasias. These lesions progressed to intraalveolar cribriform carcinomas which spread along alveoli and ducts. As the tumors enlarged, they became nodular and invaded the capsule or adjacent tissues. By 33 mo., 95-100% of the rats had intraalveolar prostatic atypical hyperplasias, and 35-40% had invasive carcinoma. There was no difference between the incidence of these tumors in virgin or breeder rats. The ACI rat is a unique model for studying the etiology and pathogenesis of naturally occurring prostatic cancer.This publication has 7 references indexed in Scilit:
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