Fungal detoxication. 3. The metabolism of ω-(2-naphthyloxy)–n-alkylcarboxylic acids by Sclerotinia laxa

Abstract

By the use of Sclerotinia laxa in a replacement-culture technique, gamma-(2-naphthyloxy)-n-butyric and 6 -(2-naphthyloxy)-n-valeric acids underwent [beta]-oxidation to the corresponding acetic and propionic acids respectively. Similarly, [beta]-naphthol was isolated in small amounts from [beta]-(2-naphthyloxy)-propionic acid; the fungistatic activity of the former was higher at pH 7 but lower at pH 2.7. Nuclear hydroxylation by S. laxa was virtually absent.