Calix[4]arenes carrying H, tert-butyl, and cyanomethyl groups in the p-positions are converted into tetraesters by aroylation or acylation in the presence of 1-methylimidazole or sodium hydride. Aroylation or acylation of p-cyanomethylcalix[4]arene in the presence of aluminum chloride yield the 1,3-diesters which, upon further aroylation or acylation, provide a variety of tetraesters of mixed functionality.