"Accelerator Globulin" and "Antihemophilic Globulin" in Thrombin Formation from Aged Prothrombin and in Hemophilic Blood.

Abstract

Simple aging for a wk. or so at room temp. lessens the thrombin-yielding ability of prothrombin (as tested with optimal amts. of the classical activators, Ca and tissue thromboplastin), apparently due to loss of a labile agent which is present in adequate traces in the original prothrombin prepn. From similarity of behavior, this agent is believed to be the newly recognized accessory factor "accelerator globulin" (AcG). AcG does not significantly aid the clotting of hemophilic blood, in contrast to "antihemophilic globulin". Present prepns. of the latter, however, retard rather than aid in thrombin formation from both fresh and aged prothrombin solns.