Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles
- 1 January 2003
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 20 (3), 409-416
- https://doi.org/10.1023/a:1022604120952
Abstract
Purpose.It has recently been suggested that the poly(butylcyanoacrylate) (PBCA) nanoparticle drug delivery system has a generalized toxic effect on the blood-brain barrier (BBB) (8) and that this...Keywords
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