Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles
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- 1 January 2003
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 20 (3), 409-416
- https://doi.org/10.1023/a:1022604120952
Abstract
Purpose.It has recently been suggested that the poly(butylcyanoacrylate) (PBCA) nanoparticle drug delivery system has a generalized toxic effect on the blood-brain barrier (BBB) (8) and that this...Keywords
This publication has 21 references indexed in Scilit:
- Interaction of Poly(butylcyanoacrylate) Nanoparticles with the Blood-Brain Barrierin vivoandin vitroJournal of Drug Targeting, 2001
- In vitro model for evaluating drug transport across the blood–brain barrierAdvanced Drug Delivery Reviews, 1999
- Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated NanoparticlesPharmaceutical Research, 1999
- Delivery of Loperamide Across the Blood-Brain Barrier with Polysorbate 80-Coated Polybutylcyanoacrylate NanoparticlesPharmaceutical Research, 1997
- Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo ModelsJournal of Neurochemistry, 1992
- Permeability of bovine brain microvessel endothelial cells in vitro: Barrier tightening by a factor released from astroglioma cellsExperimental Cell Research, 1992
- An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In VitroJournal of Neurochemistry, 1990
- PHARMACOKINETICS OF DALARGINE1988
- Toxicity of Polyalkylcyanoacrylate Nanoparticles I: Free NanoparticlesJournal of Pharmaceutical Sciences, 1982
- Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures.1972