Removal and Addition of Bile in the Intestine, and Pancreatic Colipase Activity in the Pig: Effect of a High-Lipid Diet

Abstract

The effects of the removal and addition of bile in the intestine on the tissue pancreatic colipase of pigs fed a high-lipid diet (25% peanut oil) were investigated. Experiments were carried out on fistulated pigs. In 1 group of animals, bile was removed for 8 days; in a 2nd group, an excess of bile was added in the intestine for 8 days. Results were compared to those obtained in pigs in which the collected bile was entirely returned. When bile was removed, the tissue enzyme activities of pancreatic lipase and colipase significantly decreased; the latter increased when bile was added in the intestine of pigs whose enterohepatic cycle was fully maintained.