Pancreatic secretion in rat: effect of bile stasis and of bile salt

Abstract

Obstruction of the common bile duct in the rat (albino, Rockland strain) stimulated pancreatic secretion beginning several hours after obstruction, and lasting as long as 7 days. Bile acid (sodium dehydrocholate) injected intraperitoneally did not change basal pancreatic secretion, but did increase bile secretion. When secretin injection was followed by bile acid, there was a marked increase over the secretin-stimulated secretion. Clinical implications of this mechanism are discussed.