Genetic models of schizophrenia
- 1 April 1982
- journal article
- research article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 65 (4), 263-275
- https://doi.org/10.1111/j.1600-0447.1982.tb00846.x
Abstract
Multiple threshold models of inheritance are applied to a large sample of Franz Kallmann''s pedigree data on schizophrenia. Paranoid and nonparanoid subtypes are represented in the models at different thresholds on a continuum of genetic-environmental liability. Single major locus and multifactorial-polygenic inheritance are ruled out as modes of transmission. The paranoid-nonparanoid dichotomy evidently cannot be used as a genetic threshold determinant in the population studied.Keywords
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