EFFECTS OF PROLONGED COLD-STORAGE ON THE RESPONSIVENESS OF ISOLATED AND PERFUSED CANINE INTERMEDIATE AURICULAR ARTERY
- 1 January 1985
- journal article
- research article
- Vol. 275 (1), 13-21
Abstract
Using the cannula inserting method, the effects of prolonged cold storage (5-7 days, at 4.degree. C) on vasoconstrictor responses of the isolated and perfused canine intermediate auricular artery to norepinephrine, tyramine, serotonin, histamine, prostaglandin F2.alpha. and potassium chloride were investigated. The vasoconstrictor responses to norepinephrine and potassium chloride were slightly enhanced by prolonged cold storage but not significantly, and those to serotonin and prostaglandin F2.alpha. were not influenced at all. The dose-response curve for tyramine shifted to the right in a parallel manner, and histamine-induced vasoconstriction was markedly potentiated by prolonged cold storage in a maximal increase in perfusion pressure. Evidently, prolonged cold storage on the isolated canine intermediate auricular artery may not cause complete denervation of adrenergic nerve fibers and responsiveness to vasoactive substances except histamine remains almost the same in non-stored vessels.This publication has 8 references indexed in Scilit:
- VASCULAR-RESPONSES OF ISOLATED CANINE INTERMEDIATE AURICULAR ARTERY TO VASOACTIVE SUBSTANCES1984
- VASOCONSTRICTOR RESPONSES OF ISOLATED AND PERFUSED CANINE MESENTERIC-ARTERIES TO ALPHA-ADRENOCEPTOR AGONISTS1984
- Potentiating effect of methysergide on norepinephrine-induced constriction of the isolated internal carotid artery of the dog.The Japanese Journal of Pharmacology, 1984
- A new method for measuring vascular responsiveness of relatively larger arteries of dogsJournal of Pharmacological Methods, 1983
- DISSOCIATION OF SUPERSENSITIVITY TO NOREPHINEPHRINE CAUSED BY COCAINE FROM INHIBITION OF H3-NOREPINEPHRINE UPTAKE IN COLD-STORED SMOOTH MUSCLE1969
- THE INFLUENCE OF SYMPATHETIC INNERVATION ON VASCULAR SENSITIVITY TO NORADRENALINEBritish Journal of Pharmacology and Chemotherapy, 1967
- THE INTERACTION OF SEROTONIN AND NORADRENALINE ON THE PERFUSED ARTERYBritish Journal of Pharmacology and Chemotherapy, 1966
- The effect of low temperatures on the responses of arteries to constrictor drugsThe Journal of Physiology, 1958