Normal Response to Erythropoietin or Hypoxia in Rats Made Anemic with Turpentine Abscess.

Abstract

Rats with a turpentine abscess developed characteristic mild anemia. Such rats showed an erythropoietic response comparable to that of normal controls following treatment with human urinary erythropoietin or exposure to hypoxia. Therefore, the rat having a turpentine abscess is capable of producing erythropoietin and the marrow is capable of responding when stimulated, suggesting that the mild anemia which accompanies a turpentine abscess does not serve as an adequate stimulus for increased red cell production.