The action of amoebicidal drugs on Entamoeba invadens Rodhain, 1934 in vitro
- 1 May 1954
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 44 (1-2), 132-143
- https://doi.org/10.1017/s0031182000018849
Abstract
1. A method, based on that devised for E. histolytica by Dobell (1947), was worked out for testing the action of drugs upon E. invadens.2. The sensitivity of di- and monobacterial strains of E. invadens to emetine was determined, and of a dibacterial strain to the quinaldines A 352, A 356 and A 404. E. invadens was killed by emetine at concentrations of 1/50,000–1/100,000, A 352 or A 356 at 1/100,000, and A 404 at 1/10,000. The strains of E. invadens used in the present tests are thus less sensitive to emetine than is E. histolytica, but the sensitivity of the two species to the quinaldines is similar.3. A strain of E. invadens which was maintained for 9 months in the presence of increasing concentrations of emetine, did not become resistant to the drug.I am indebted to Dr A. Bishop for much advice and criticism; to Dr J. D. Fulton for a culture of Bacterium coli A'; and to Dr J. Walker for supplies of the compounds A 352, A 356 and A404. The work has been financed by the Medical Research Council.Keywords
This publication has 16 references indexed in Scilit:
- Researches on the intestinal Protozoa of monkeys and manParasitology, 1952
- Evidence of Direct Amebacidal Action of Agents Tested In vitro against Endamoeba histolyticaJournal of Parasitology, 1951
- Amoebicidal action and chemical constitutionProceedings of the Royal Society of London. B. Biological Sciences, 1950
- Cultivation of Endamoeba histolytica with Trypanosoma cruziScience, 1950
- Nature of the Action of Emetine upon Entamæba histolyticaNature, 1949
- Morphology and Life-cycle of an Amoeba Producing Amoebiasis in ReptilesParasitology, 1936
- Amebiasis in ReptilesScience, 1934
- Experiments on the Action of Emetine in Cultures of Entamoeba Coli.Parasitology, 1929
- Further Experiments on the Action of Emetine in Cultures of Entamoeba histolyticaParasitology, 1928
- The Action of Ipecacuanha Alkaloids on Entamoeba histolytica and some other Entozoic Amoebae in CultureParasitology, 1926